Medical Short List Linking Hepatitis B Vaccine to Various Pathologies

The development of rheumatoid arthritis after recombinant hepatitis B vaccination J Rheumatol 1998 Sep;25(9):1687-93. The clinical, serologic, and HLA antigens of a cluster of firefighters who developed arthritis after prophylactic recombinant hepatitis B vaccination (5 subjects), as well as a second group of sporadic cases of arthritis (6 patients) after hepatitis B vaccination are described.
Pulmonary and cutaneous vasculitis following hepatitis B vaccination Thorax 1993 48(5):580-1.
Lichen planus following hepatitis B vaccination Arch Dermatol 1994 130(10):1329-1330.
Lichen planus after hepatitis B vaccination. 3 new cases Presse 1997 Med 26(16):760.
Central nervous system disease in patients with macrophagic myofasciitis Brain 2001 124(Pt 5):974-83. Aluminium-containing vaccines had been administered 3–78 months (median = 33 months) before muscle biopsy (hepatitis B virus: four out of seven, tetanus toxoid: one out of seven, both hepatitis B virus and tetanus toxoid: two out of seven). The association between MMF and multiple sclerosis-like disorders may give new insights into the controversial issues surrounding vaccinations and demyelinating CNS disorders.
Benign acute pericarditis after vaccination against hepatitis B Presse Med 1993 Feb 20;22(6):269.
Bilateral neuro-papillitis after hepatitis B vaccination Presse Med 1996 Sep 28;25(28):1301.
A case of segmentary unilateral occlusion of the central retinal vein following hepatitis B vaccination Presse Med 1997 Apr 26;26(14):670.
Multifocal placoid epitheliopathy and anti-hepatitis B vaccination J Fr Ophtalmol 1998 Nov;21(9):696-700. The appearance of ocular pathological outcomes following an hepatitis B vaccination is uncommon. Among them, acute multiple posterior placoid pigment epitheliopathy has been noticed after injections of Engerix B recombinant vaccine. We describe the case of an 11-year-old child who presented this affection following a Genhevac B recombinant vaccine injection.

Polyarthritis associated with hepatitis B vaccination Br J Rheumatol 1997 Feb;36(2):300-1.
Erosive polyarthritis triggered by vaccination against hepatitis B Presse Med 1997 Feb 1;26(2):75.
Arthritis induced by antihepatitis B vaccine An Med Interna 1999 Nov;16(11):601-2.
Reactive arthritis following vaccination against hepatitis B Ugeskr Laeger 1987 Jul 6;149(28):1882.
Reiter’s syndrome and reactive arthritis in health care workers after vaccination BMJ 1994 July 9; 309(6947): 94.
Arthritis after hepatitis B vaccination. Report of three cases Scand J Rheumatol 1995;24(1):50-2. These three cases show that arthritis after hepatitis B vaccination probably is more common than reported so far, especially in a genetically predisposed subject (two of our patients expressed HLA-DR4).
Lumbosacral acute demyelinating polyneuropathy following hepatitis B vaccination Autoimmunity 1999;30(3):143-6. We report a patient who presented with an acute inflammatory demyelinating polyneuropathy, that followed the second injection of a hepatitis B vaccination, and characterized by motor and sensory deficit restricted to lower limbs and perineum, and persistent bladder dysfunction. The relationship between the preceding event and neurological disease is discussed.
Guillain-Barré syndrome following hepatitis B vaccination Clin Exp Rheumatol 2004 Nov-Dec;22(6):767-70.
Anetoderma after hepatitis B immunization in two siblings J Am Acad Dermatol 1997 May;36(5 Pt 1):779-80.
Occlusion of central retinal vein after hepatitis B vaccination Lancet 1996 Jun 8;347(9015):1626.
Erythema nodosum provoked by hepatitis B vaccine Lancet 1986 November 1;328,Issue 8514:1042
Juvenile dermatomyositis concomitant with hepatitis B vaccination Med Clin (Barc) 1998 Nov 21;111(17):675.
Reiter’s syndrome attributed to hepatitis B immunisation BMJ 1994 December 3; 309(6967): 1513.
Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine Arch Dis Child 1998 Mar;78(3):273-4. Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded.
Thrombocytopenic purpura after hepatitis B vaccine: case report and review of the literature Pediatr Infect Dis J 2004 Feb;23(2):183-4.
Uveitis after hepatitis B vaccination Lancet 1987 September 12;330 Issue 8559:631-2.
Hepatitis B vaccine and uveitis: an emerging hypothesis suggested by review of 32 case reports Cutan Ocul Toxicol 2010 Mar;29(1):26-9. Hepatitis B vaccine may have a possible association with the development of uveitis in some patients. Immune complex deposition and adjuvant effects are potential pathogenic mechanisms.
Peripheral facial paralysis following vaccination against hepatitis B. Apropos of a case Therapie 1992 Sep-Oct;47(5):437-8.
A case of severe cytolysis after hepatitis B vaccination Am J Med 1995 Jun;98(6):595-6.
Mental nerve neuropathy as a result of hepatitis B vaccination Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Jun;83(6):663-4.
Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle Brain 2001 Sep;124(Pt 9):1821-31.
Adult-onset Still’s disease after hepatitis A and B vaccination Rev Med Interne 1998 Feb;19(2):134-6.
Adult onset Still disease and subacute thyroiditis Rev Med Interne 1996;17(5):427.
Acute aseptic meningitis after hepatitis B vaccination Presse Med 1997 Mar 8;26(7):328.
Aluminum hydroxide granuloma following hepatitis B vaccination Dtsch Med Wochenschr 1990 Mar 23;115(12):476.
Nephrotic syndrome following hepatitis B vaccination Pediatr Nephrol 2000 Jan;14(1):89-90.
Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype J Neurol Neurosurg Psychiatry 1995 Jun;58(6):758-9.
A case of intense cytolysis following the administration of a hepatitis B vaccine Rev Clin Esp 1999 Jan;199(1):49-50.
Anaphylaxis after hepatitis B vaccination Lancet 1995 May 13;345(8959):1249.
Periarteritis nodosa following vaccination against hepatitis B Presse Med 1988 Oct 8;17(34):1763.
Systemic polyarteritis nodosa following hepatitis B vaccination Eur J Intern Med 2008 Dec;19(8):575-8. After reviewing the 27 cases of vasculitis after hepatitis B vaccination reported in the current literature, the authors suggest that, in some cases, vaccination may be the triggering factor for vasculitis in individuals with a genetic predisposition. Physicians should be aware of this possible association.

Suspected hepatitis B vaccination related vasculitis J Rheumatol 1999 Jan;26(1):191-4. We describe 3 cases of vasculitis occurring after such immunization that are thought to have been vaccine induced. Vasculitides are now recognized as possible severe adverse side effects of immunization.
Pulmonary and cutaneous vasculitis following hepatitis B vaccination Thorax 1993 May; 48(5): 580–581. The case history is presented of a previously healthy non-atopic woman who developed cutaneous vasculitis, confirmed by biopsy, and pulmonary problems after inoculation with recombinant hepatitis B vaccine.
Rheumatic disorders developed after hepatitis B vaccination Rheumatology 1999 38(10):978-83.
Lupus erythematosus disseminatus and vaccination against hepatitis B virus Arch Pediatr 1994 Mar;1(3):307-8.
Meningeal reaction after vaccination against hepatitis B Presse Med 1996 Oct 26;25(32):1561-2.
Evans’s syndrome triggered by recombinant hepatitis B vaccine Clin Infect Dis 1992 Dec;15(6):1051.
Hypersensitivity vasculitis after hepatitis B vaccination Presse Med 1998 Jun 6;27(20):965-6.
Cryoglobulinemia after hepatitis B vaccination N Engl J Med 1996 Aug 1;335(5):355.
Eosinophilia after intradermal hepatitis B vaccination Lancet 1993 Oct 16;342(8877):998.
Sudden hearing loss in childhood consequent to hepatitis B vaccination: a case report Ann N Y Acad Sci 1997 Dec 29;830:319-21.
Acute pericarditis after vaccination against hepatitis B: a rare effect to be known Rev Med Interne 1997;18(8):675-6.
Solitary mastocytoma arising at a hepatitis B vaccination site Cutis 1999 Jan;63(1):37-40. On the first day of life, a healthy infant was given a recombinant hepatitis B vaccine. Over the following year, a 3 by 4.5 cm, well-defined, erythematous patch with an overlying white, reticulated, smaller plaque gradually appeared on her thigh at the vaccination site. Darier’s sign was elicited at the site. Examination of a biopsy specimen showed an upper dermal mast cell infiltrate. This is the first reported case of a solitary mastocytoma appearing in a vaccination site.
First case of erythermalgia related to hepatitis B vaccination J Rheumatol 1999 Jan;26(1):233-4.
Neuralgic amyotrophy following recombinant DNA hepatitis B vaccination Muscle Nerve 1990 May;13(5):461.
Exacerbation of chronic juvenile arthritis induced by hepatitis B vaccination Arch Pediatr 1998 Sep;5(9):1046.
Persistent nodules at sites of hepatitis B vaccination due to aluminium sensitization Contact Dermatitis 1998 Sep;39(3):135-6.
Eczematous reaction to hepatitis B vaccine Contact Dermatitis 1999 Mar;40(3):158-9.
Acute Myelitis after hepatitis B vaccination Presse Med 1993 Dec 18;22(40):1997-8. We report a case of myelitis after plasma-derived hepatitis B vaccination. The patient was a 31-year-old man who presented with progressive sensory symptoms in extremities that developed 2 weeks after a third vaccination. MRI of the cervicothoracic region revealed swelling and T2 high signal at the level of C4 to C5 cord, and isolated enhancement in the posterior columns between C4 and C5 cord…
Subacute thyroiditis after hepatitis B vaccination Endocr J. 1998 Feb;45(1):135.
Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS Neurology 1999 Jul 22;53(2):396-401.
Erosive nodular rheumatoid arthritis triggered by hepatitis B vaccination Presse Med 1997 Apr 26;26(14):670.
Transverse myelitis following hepatitis B vaccination J Hepatol 1993 Sep;19(2):317-8.
A case of Churg-Strauss vasculitis after hepatitis B vaccination Ann Rheum Dis 1998 Apr;57(4):256-7.
Acute sero-positive rheumatoid arthritis occurring after hepatitis vaccination Br J Rheumatol 1994 Oct;33(10):991.
Hepatitis B vaccine adverse events: citations – Whale.to