Link Between Neurological and Immune Disorders
Contents
Aluminum
- Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum The dosing of aluminum in vaccines is based on the production of antibody titers, not safety science. Here we estimate a Pediatric Dose Limit that considers body weight. We identify several serious historical missteps in past analyses of provisional safe levels of aluminum in vaccines, and provide updates relevant to infant aluminum exposure in the pediatric schedule considering pediatric body weight. When aluminum doses are estimated from Federal Regulatory Code given body weight, exposure from the current vaccine schedule are found to exceed our estimate of a weight-corrected Pediatric Dose Limit.
- The measurement and full statistical analysis including Bayesian methods of the aluminium content of infant vaccines Aluminium adjuvants are critical to the efficacy of vaccines and are far from being benign components. Information on their content, activity and safety is severely lacking and this void requires urgent attention. Until such information is forthcoming, aluminium adjuvants remain prime suspects in widely documented vaccination-related adverse events.
- Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity We conclude that Alhydrogel® injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects.
- Slow CCL2-dependent translocation of biopersistent particles from muscle to brain Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs, such as spleen and brain where they were still detected one year after injection. … This occurs at a very low rate in normal conditions explaining good overall tolerance of alum despite its strong neurotoxic potential. However, continuously escalating doses of this poorly degradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier or high constitutive CCL-2 production.
- Aluminum vaccine adjuvants: are they safe? We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.
- Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
- Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
- Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction
- Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF) Long-term follow-up of a subset of patients with 3 or 4 consecutive neuropsychological evluations confirmed the stability of MACD [Macrophagic myofasciitis-associated cognitive dysfunction] with time, despite fluctuations.
- Aluminum adjuvant linked to Gulf War Illness induces motor neuron death in mice
- The immunobiology of aluminium adjuvants: how do they really work?
- Aluminum inclusion macrophagic myofasciitis: a recently identified condition The authors conclude that the persistence of aluminum hydroxide at the site of intramuscular injection is a novel finding which has an exact significance that remains to be established fully. It seems mandatory to evaluate possible long-term adverse effects induced by this compound, because this issue has not been addressed (in the past, aluminum hydroxide was believed to be cleared quickly from the body).
- Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle We conclude that (i) intracytoplasmic inclusions are constantly detected in MMF [Macrophagic myofasciitis] lesions and correspond to aluminum hydroxide crystals; (ii) MMF lesions are secondary to intramuscular injections of aluminum hydroxide-containing vaccines and should be regarded as post-vaccinal immunogenic granuloma; and (iii) MMF lesions are usually detected in the deltoid muscles of patients with diffuse myalgias appearing subsequently to aluminum hydroxide-containing vaccine administration.
- A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.
- Aluminum as an adjuvant in Crohn’s disease induction
- Aluminum is a potential environmental factor for Crohn’s disease induction: extended hypothesis
- Aluminum studies compiled by CMSRI Children’s Medical Safety Research Institute
Mercury
Other Mercury-related Resources
(Also see Autoimmune Disease and Death..)
Neurological and Immunological Development
- Novel Roles for Immune Molecules in Neural Development: Implications for Neurodevelopmental Disorders
- The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease Although a link between behavior and immune function has been hypothesized for many decades, recent work provides some of the most compelling evidence thus far. In particular, autoimmune synaptic encephalitides demonstrate how abnormal autoimmune targeting of synaptic proteins can result in profound neuropsychiatric symptoms. Each syndrome is diagnosable by a set of laboratory tests and responds well to immunotherapy. These features provide a degree of clinical certainty rarely available to psychiatrists. Also, the high incidence of systemic autoimmune disorders with neuropsychiatric features reinforces the likely cross-reactivity of peripheral autoantibodies with brain antigens…Finally, and perhaps most significantly, new research will aim to determine whether a subset of what we currently diagnose as primary psychiatric disorders are in fact due to definable, treatable autoimmune syndromes.
- Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study Because primate testing is an important aspect of pre-clinical vaccine safety assessment prior to approval for human use, the results of this pilot study warrant additional research into the potential impact of an interaction between the MMR and thimerosal-containing vaccines on brain structure and function.
- Primary Immunization of Premature Infants with Gestational Age <35 Weeks: Cardiorespiratory Complications and C-Reactive Protein Responses Associated with Administration of Single and Multiple Separate Vaccines Simultaneously
- Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages Neonatal humans and rodents are susceptible to infection with encapsulated bacteria as a result of an inability to make antibodies to capsular polysaccharides….In this study, we show that when stimulated with a variety of agonists to TLR2, -4, and -9, neonatal [splenic macrophages] make less proinflammatory cytokines and more IL-10 than adult [splenic macrophages].
- Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children.
- Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccines Thimerosal at concentrations relevant for infants’ exposure (in vaccines) is toxic to cultured human-brain cells and to laboratory animals.
- Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts
- Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism
- Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little? A central question that emerges is whether immune and inflammatory pathways become hyperactivated with age and promote degeneration or whether insufficient immune responses, which fail to cope with age-related stress, may contribute to disease.
(Also see the Mercury section above and the Neurological and Immune Dysfunction section below.)
Neurological and Immune Dysfunction
Specific Vaccines
